HLA-DQ: Celiac diseasevsinflammatory bowel disease
نویسندگان
چکیده
منابع مشابه
HLA-DQ: Celiac disease vs inflammatory bowel disease
AIM To determine the genetic predisposition to celiac disease (CeD) in inflammatory bowel disease (IBD) patients by quantifying the frequency of CeD-related human leucocyte antigen (HLA) (HLA-CeD: HLA-DQ2 and -DQ8) in IBD patients globally, by type of IBD and gender, and by calculating the protective/risk contribution of these haplotypes in the development of the IBD disease. METHODS We condu...
متن کاملEVIDENCE FOR A PRIMARY ASSOCIATION OF CELIAC DISEASE TO A PARTICULAR HLA-DQ a/ß HETERODIMER
Celiac disease (CD) is a malabsorptive disorder precipitated in genetically susceptible individuals by ingestion ofgluten . A significant part of the disease predisposition maps to the HLA class II region, but the primary HLA association is not known (1) . DR3 seems to be a susceptibility allele together with any other DR allele while DR7 is associated to CD almost only in combination with DR3 ...
متن کاملAccuracy of serologic tests and HLA-DQ typing for diagnosing celiac disease.
BACKGROUND Estimates of the diagnostic performance of serologic testing and HLA-DQ typing for detecting celiac disease have mainly come from case-control studies. OBJECTIVE To define the performance of serologic testing and HLA-DQ typing prospectively. DESIGN Prospective cohort study. SETTING University hospital. PATIENTS Patients referred for small-bowel biopsy for the diagnosis of cel...
متن کاملEvidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer
Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene. These genes are arranged in cis position on the DR3DQw2 haplotype and in trans position in DR5DQw7/DR7DQw2 heterozygous individuals. Thus, most CD patients may share ...
متن کاملHLA-DQ genetic risk gradient for type 1 diabetes and celiac disease in northwestern Mexico.
BACKGROUND Type 1 diabetes (T1D) and celiac disease (CD) are the 2 most common autoimmune childhood diseases that share their HLA-DQ2 and DQ8 genetic origin. There has currently been an increase in both diseases worldwide. In children from the low-population State of Sonora (15 inhabitants/km(2)) in north-western Mexico, there is no information on their genetic risk or the distribution of the r...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2018
ISSN: 1007-9327
DOI: 10.3748/wjg.v24.i1.96